Article Summary: The Mittendorf dot, an embryologic remnant of the hyaloid artery, is an exam finding of a posterior lens capsule circular opacity that is most commonly visually insignificant.
The Mittendorf dot, discovered by William Frederick Mitttendorf, is a congenital vascular abnormality which occurs due to an involutional defect of the anterior terminus of anterior hyaloid artery. It manifests as a focal opacity in the infero-nasal aspect of the posterior lens capsule. It is a clinical variant of persistent fetal vasculature (PFV), a spectrum of conditions that arise when fetal hyaloid vasculature fails to involute. The Mittendorf dot is thought to be attached to the posterior lens capsule itself; recent evidence, however, shows the possibility of a retrolental presence of the dot in the anterior vitreous. The evidence suggests that the Mittendorf dot can in fact be located posterior to Erggelet’s space (retrolental space of burger)- the space between the posterior capsule and the vitreous as depicted in the illustration below. A lone Mittendorf dot is a relatively benign finding rarely causing visual impairment.
The hyaloid artery is a transient vessel that extends from the optic disc to the posterior pole of the lens during fetal development. A dense network of intraocular vessels branch from the hyaloid artery and proliferate during early embryogenesis in order to supply the developing ocular tissues and contribute to the primary vitreous. This hyaloid vasculature ultimately begins to involute at two to three months gestation, coinciding with the development of the retinal vasculature. Following involution, the perivascular sheath of the hyaloid artery typically remains forming Cloquet’s canal. This is seen in the image below (figure 2).
The underlying mechanism responsible for involution of this vascular system is theorized to involve apoptosis via a combination of macrophage activation and cessation of blood flow to the hyaloid artery and its branches. The cellular signaling that leads to macrophage activation has yet to be elucidated.
Mittendorf dot develops when the anterior terminus of the hyaloid artery fails to involute leaving behind an embryologic remnant. The proposed mechanisms causing persistent fetal vasculature involves improper gene expression of a number of molecules and growth factors including, but not limited to, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), angiopoietin 2, Arf tumor suppressor gene, and collagen 18. This remains an active area of research.
In cases where direct visualization is precluded, computed tomography (CT), magnetic resonance imaging (MRI), intravenous fluorescein angiography, or ultrasonography are other techniques which can be utilized to visualize the pathology.
== Signs == 
Upon physical examination, a Mittendorf dot may be seen in the inferonasal quadrant on the posterior lens capsule. It is apt to be overlooked due to its small size and general lack of symptoms.
The prognosis for Mittendorf dot is excellent as the embryologic remnant is not typically visually significant and does not progress. The Mittendorf dot should be monitored with ophthalmologic examinations including gonioscopy of the anterior chamber at regular intervals. For premature infants, up to 95% can demonstrate some form of hyaloid remnants including Mittendorf dots which usually disappear as the infant matures. Persistence of hyaloid remnants remains low at approximately 3%. Intervention is rarely necessitated.
Complications associated with Mittendorf dots are rare. As a general rule, complications associated with more extensive PFV such as vitreous hemorrhage, retinal detachment, swollen lens, or glaucoma are possible. A Mittendorf dot can also present as a larger opacity that spans the entirety of the posterior lens capsule. A “brittle-star” formation may be observed if the Mittendorf dot anastomoses with other residual fetal vasculature.
- Goldberg, M. F. (1997). Persistent fetal vasculature (PFV): an integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV) LIV Edward Jackson Memorial Lecture. American journal of ophthalmology, 124(5), 587-626.
- Saint-Geniez, M., & D'Amore, P. A. (2004). Development and pathology of the hyaloid, choroidal and retinal vasculature. The International journal of developmental biology.
- Tassignon M-J. (2019). Clinical Variations of the Vitreo-lenticular Interface. In: Innovative Implantation Technique. Springer International Publishing; 33-42.
- E. Santos-Bueso. (2019) Berger’s space. Archivos de la Sociedad Española de Oftalmología (English Edition), Volume 94, Issue 10, Pages 471-477. ISSN 2173-5794. https://doi.org/10.1016/j.oftale.2019.06.003.
- Farber, N. C., MD, & Shrier, E. M., DO. (2015, February 05). How to treat persistent fetal vasculature. Retrieved April 02, 2021, from https://www.reviewofophthalmology.com/article/how-to-treat-persistent-fetal-vasculature
- Czepita, M., Szewczyk, A., & Twarużek, J. (2017). Mittendorf’s dot and posterior embryotoxon—incidental findings in a patient with a potentially occludable anterior chamber angle. Ophthalmology Journal, 2(4), 110-112.
- Sheth, J. U., Sharma, A., & Chakraborty, S. (2013). Persistent hyaloid artery with an aberrant peripheral retinal attachment: A unique presentation. Oman journal of ophthalmology, 6(1), 58.
- Jones, H. E. (1963). Hyaloid Remnants In the Eyes of Premature Infants. British Journal of Ophthalmology, 47(1), 39–44. https://doi.org/10.1136/bjo.47.1.39