Talk:Normal Tension Glaucoma

Missing references

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Systemic vascular disease

• Similarly, it has been suggested that Obstructive Sleep Apnea (OSA) may lead to transient episodes of nocturnal hypoxemia and compromised optic nerve head perfusion. In fact, a higher prevalence of OSA among NTG patients has been noted in several studies [58] [59] [60]. Moreover, one study demonstrated a correlation between moderate/severe OSA and higher progression of RNFL loss [61].

Medical therapy

• Moreover, Rho-kinase inhibitors are thought to be neuroprotective and increase vascular flow at the ONH via the nitric oxide pathway [65] [66]. Further trials are needed to identify ideal medical therapy in patients with NTG.

Surgery

• However, recent trends and practice patterns according to the AAO Intelligent Research Insight Registry (IRIS) reveal a significant increase in the use of MIGS procedures from 2013-2018, and NTG is no exception [63].
• According to AAO IRIS data regarding initial surgery for NTG, iStent has been the most common performed surgery and MIGS procedures in general are performed at a higher rate than filtration surgeries for NTG [64].
• One recent study demonstrated a mean IOP decrease of 5.6 +/- 2.7 mmHg in NTG patients, which represented an IOP reduction of 29% [67].