Linear Interstitial Keratitis

From EyeWiki
All authors and contributors:
Assigned editor:
Assigned status Update Pending

Article summary goes here.

Disease Entity

Linear Interstitial Keratitis (LIK) is a rare linear stromal lesion of the cornea that has been reported in young adults as early as 1923 [1].


Add text here


Once postulated to be spurred by syphilitic infection, we now know from case reports that anti-treponemal antibodies are generally absent, suggesting positive serology as an incidental finding [1]. The etiology remains unknown, and histology from perforated corneas with LIK undergoing patch grafting has proven unrevealing [1].

General Pathology

Add text here


Syphilis and Lyme were once implicated in the etiology of this condition, but serologies in patients with LIK have been equivocal without clear positivity across all case reports [1, 3, 4]. Petrovic et al suggest that this condition derives from autoimmunity.


Linear corneal opacification with central thinning in LIK [1]

Diagnosis is clinical based on the linear appearance of the opacity and its response to steroid therapy. Laboratory serologies for Lyme and Syphilis may


Add text here

Physical examination

Add text here


Add text here


Add text here

Clinical diagnosis

Add text here

Diagnostic procedures

Diagnosis is clinical based on the linear appearance of the corneal opacity

Differential diagnosis

Interstitial keratitis

Herpes disciform endotheliitis

Herpes necrotizing keratitis

Bacterial keratitis

Fungal keratitis


Neurotrophic keratitis,


Add text here

General treatment

Add text here

Medical therapy

Add text here

Medical follow up

Add text here


Penetrating keratoplasty may be performed for perforation, but surgery is not typically recommended.

Surgical follow up

Add text here


Add text here


The prognosis for recovery with steroid use appears to be good; however, inflammation tends to recur.


1.         Calvo, C.M., et al., Linear interstitial keratitis: a distinct clinical entity revisited. Cornea, 2012. 31(12): p. 1500-3.

2.         Rapuano, C., Cornea : Cornea. 2018, Philadelphia, Untied States: Wolters Kluwer.

3.         Petrovic, A., et al., Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography. Cornea, 2018. 37(6): p. 785-788.

4.         Direev, A.O. and V.V. Chernykh, A clinical case of linear stromal (interstitial) keratitis. Acta biomedica scientifica, 2022. 7(4): p. 88-94.

  1. Illinois Eye and Ear Infirmary, shared with patient guardian permission
The Academy uses cookies to analyze performance and provide relevant personalized content to users of our website.