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Summary

Facial lentigines and ocular abnormalities in patients of different ethnicities who have xeroderma pigmentosum (XP). A, Case 1 is a 5-year-old African American XP-C patient (XP444BE) with lentigines on her skin. B, Case 2 is a 13-year-old First Nations XP-C patient (XP83BE) with many lentigines, ocular surface injection, and sunburn. C, Case 3 is a 39-year-old Hispanic XP-C patient (XP131BE) who is originally from the Dominican Republic. The patient has a history of skin cancer but no history of eyelid or ocular surface cancer. Many prominent lentigines are seen on her face and neck. The patient was fairly darkly pigmented when younger, but now pigmentation has been lost, resulting in hypopigmented areas. D, Case 4 is a 46-year-old Caucasian XP-C patient (XP1BE). 33–35 She underwent bilateral orbital exenteration at ages 32 and 36 years because of recurring invasive squamous cell carcinoma of the ocular surfaces and basal cell carcinoma of the lids, including 1 squamous cell carcinoma that occurred on the palpebral conjunctiva of the upper eyelid, a non–sun-exposed area. 36 This patient, originally light-skinned, has many darkly pigmented lentiginous areas on her face. She died of uterine cancer at age 49 years. Ocular Manifestations of Xeroderma Pigmentosum, Ophthalmology, Volume 120 Issue 7 Pages 1324-1336 (July 2013)