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Enter the name of the assigned editor for this page. Enter the name of the reviewer for this page. "Parul.Ichhpujani"67.142.130.44A.Nicole.SomaniA.Paula.GrigorianALBERTO CALVO ÁLVAREZAMIR ABDULAMEER.MADHLOOMANAIS.CARNICIUANKITA AISHWARYAASHRAF.ELBATARNYAa hfzAakriti.GargAalsuhaibaniAaron.Lindeke-MyersAaron.M.Miller.EICAashish.PantAbanoob TadrosseAbdala.SirajeldinAbdulaziz.Anazi.AlshamraniAbdulla.EllaithyAbdullah. GalalAbdullah.GalalAbdulrahman.Faisal.AlBloushiAbhishek.PaulAbhishek.sheemarAbigail.GordonAbraham.SarabiaAbubakar.dogoAcef AssaudAcef.AssaudAcp1961Acs97388AdaAda.Carol.Apaza.AvilaAdam.AltmanAdam.C.WeberAdam.G.ChunAdam.HartAdam.SweeneyAdam.mclaughlinAdeela M. 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{{Infobox disease | Name = {{PAGENAME}} | DiseasesDB = 11410 | ICD9 = | ICD10 = {{ICD10|H|34|0}},{{ICD10|H|34|1}},{{ICD10|H|34|2}} | OMIM = | MeshID = D015356 | MedlinePlus = 001028 }} A symptomatic retinal artery occlusion is an ophthalmic emergency that requires immediate evaluation and transfer to a stroke center. It is an obstruction of retinal blood flow that may be due to an embolus causing occlusion or thrombus formation, vasculitis causing retinal vasculature inflammation, traumatic vessel wall damage, or spasm. The lack of oxygen delivery to the retina during the blockage often results in severe vision loss in the area of ischemic retina. Patients often have concurrent silent ischemic stroke.<ref>Lee J, Kim SW, Lee SC, Kwon OW, Kim YD, Byeon SH. Co-occurrence of Acute Retinal Artery Occlusion and Acute Ischemic Stroke: Diffusion-Weighted Magnetic Resonance Imaging Study. American Journal of Ophthalmology. 2014 Jun 1;157(6):1231–8.</ref> There are no evidence based treatments that have been demonstrated to have visual benefit, and a 2015 meta-analysis of fibrinolysis suggests that many interventions may be harmful or even fatal.<ref name=":2" />''<br>'' = Disease = = Etiology = [[File:Crao.jpg|thumb|Central retinal artery occlusion with cherry red spot and retinal whitening]] Retinal artery occlusion may occur in any of the vessels supplying the eye. The main artery that supplies the eye and surrounding structures is the ophthalmic artery. The central retinal artery is the first branch of the ophthalmic artery, and it supplies nerve fibers in the optic nerve as well as the inner layers of the retina. After entering the eye, the central retinal artery divides into superior and inferior branches. In addition, the cilio-retinal artery is a branch of the short posterior ciliary arteries, which is a separate branch of the ophthalmic artery. The blood-flow through any of these vessels may be disrupted during a retinal artery occlusion. Blackage may be caused by emboli, vasculitis, or spasms. Occlusion of the ophthalmic artery is often due to giant cell arteritis, while occlusion of the cilioretinal artery may be secondary to a central retinal vein occlusion, due to increased outflow resistance. = Risk Factors = The risk factors and demographics of retinal artery occlusion are similar to ischemic stroke and include several modifiable risk factors: * Older age * Male gender * Smoking * Hypertension * Obesity * Diabetes * Hyperlipidemia * Cardiovascular disease * Coagulopathy = General Pathology = Obstruction of the retinal vascular lumen by an embolus, thrombus or inflammatory/ traumatic vessel wall damage or spasm. Giant cell arteritis may also be associated with this condition. = Pathophysiology = The central retinal artery supplies the inner retina. Occlusion of the retinal arteries results in ischemia of the inner retina. When the inner retina is damaged, it first becomes very edematous. Over time, the edema resolves and the inner retina atrophies. In central retinal artery occlusion , the outer retina is perfused by the choroidal circulation and some inner retina tissue may survive, thus some vision is preserved. Over the course of about week, the occlusion may recannulate. Unfortunately, the retina is very sensitive to ischemia and animal models have demonstrated irreparable damage occurs after 105 minutes of occlusion.<ref>Hayreh SS, Zimmerman MB, Kimura A, Sanon A. Central retinal artery occlusion. Retinal survival time. Exp Eye Res. 2004 Mar;78(3):723–36.</ref><ref>Hayreh SS, Kolder HE, Weingeist TA. Central retinal artery occlusion and retinal tolerance time. Ophthalmology 1980; 87:75-78.</ref> Thus, the vision loss is often permanent with only mild visual recovery. In branch retinal artery occlusion, only part of the retina is involved. The area of retina affected by the occluded vessels is associated with the area and degree of visual loss. In contrast, ophthalmic artery artery occlusion results in ischemia of both the inner and outer retina. This results in very severe loss of vision, often resulting in no light perception. = Primary prevention = Control of modifiable risk factors is the primary prevention of this disorder. These modifiable risk factors should be aggressively managed in patients who have experienced vision loss in one eye. Ideally, this should be done in conjunction with a stroke/neurology service. The most important risk factor to manage is giant cell arteritis. Patients who are suspected to have ophthalmic artery occlusion secondary to giant cell arteritis should be started immediately on corticosteroids and continued for six to twelve months. A temporal artery biopsy may be performed 2 weeks after initiation of steroids and some authors have found positive biopsy results 4 weeks after steroid initiation.<ref>Ray-Chaudhuri N, Kiné DA, Tijani SO, Parums DV, Cartlidge N, Strong NP, et al. Effect of prior steroid treatment on temporal artery biopsy findings in giant cell arteritis. British Journal of Ophthalmology. 2002 May 1;86(5):530–2.</ref> Starting steroids in patients under the age of 50 years, in African-american patients, or patients with elevated ESR in the setting of chronic kidney disease may not be clinically indicated. A new agent, tocilizumab, may reduce the amount of time that patients need to be treated with corticosteroids. = Diagnosis = == History == Patients typically describe sudden, painless, vision loss that occurs over seconds. Visual acuity may vary depending on the location of the obstruction. Complete vision loss to no light perception should raise suspicion of an ophthalmic artery occlusion. Patients with central retinal artery occlusion (CRAO) complain of visual loss over the entire field of vision, while those with a branch retinal artery occlusion (BRAO) complain of hemifield defect A patient with cilioretinal artery sparing may have 20/20 vision. Visual loss may have been preceded by transient loss of vision in the past (amaurosis fugax) in the case of embolic sources. Sudden vision loss in a patient older than 50 years of age should immediately raise suspicion for [[Giant Cell Arteritis]]. Urgent systemic steroids may be needed to preserve vision in the affected eye and prevent vision loss in the unaffected eye (PPP strong recommendation). <ref name=":0"><nowiki>https://www.aao.org/preferred-practice-pattern/retinal-ophthalmic-artery-occlusions-ppp-2016</nowiki></ref> Diabetic patients may need close follow-up as steroids will cause hyperglycemia. Systemic evaluation for vascular occlusive disease. In young patients a vasculitis and/or hypercoagulable workup should be performed. In older patients, an embolic workup should be performed. (PPP strong recommendation)<ref name=":0" /> == Physical examination and signs == A relative afferent pupillary defect may be present in central retinal artery occlusion or ophthalmic artery occlusion. Early in the course, the fundus may appear normal. In central retinal artery occlusion, the classic findings of retinal whitening and a cherry red spot are due to opacification of the nerve fiber layer as it becomes edematous from ischemia. The fovea is cherry red because it has no overlying nerve fiber layer. This finding may take hours to develop, and the edema is associated with a worse visual prognosis. Over the course of about a month, the inner retina becomes atrophic as the swelling resolves. Examination of the retinal blood vessels shows segmental blood flow, classically described as boxcarring. This is best appreciated with slit-lamp biomicroscopy. Over about the course of a week, the vessels reperfuse. [[File:Cilioretinal artery sparing.jpg|thumb|Central retinal artery occlusion with cilioretinal artery sparing]] <br> Chronic signs of retinal artery occlusion include pale optic disc, thinned retinal tissue, attenuated vessels, retinal pigment epithelial mottling, and severely decreased vision. In the case of BRAOs, there may be artery-to-artery anastomoses. == Clinical diagnosis == Acutely, diagnosis is prompted by the sudden onset of visual acuity loss and the presence of retinal whitening. There is a corresponding field defect. The affected blood vessel shows sluggish blood-flow (boxcarring of the blood column). There may be a refractile lesion within the blood vessel (Hollenhorst plaque- cholesterol), a whitish lesion within a section of the blood vessel usually at branching (platelet-fibrin ) or large calcific plaque (cardiac valvular disease). The arteries are thinned. Veins may be thinned, slightly dilated or normal. == Diagnostic procedures == Optical coherence tomography reveals hyperreflectivity of the inner retina in acute stages. The amount of retinal edema is related to visual prognosis.<ref name=":1">Ahn SJ, Woo SJ, Park KH, Jung C, Hong J-H, Han M-K. Retinal and Choroidal Changes and Visual Outcome in Central Retinal Artery Occlusion: An Optical Coherence Tomography Study. American Journal of Ophthalmology. 2015 Apr 1;159(4):667–676.e1.</ref> Over the course of about 1 month, the inner retinal becomes atrophic and thins. Fluorescein angiography shows a delay in the filling of the retinal arteries and a delayed arteriovenous transit time in the affected areas. The flow of blood in retinal arteries are very sluggish. The front edge of fluorescein ([https://www.elsevier.com/books/retina/ryan/978-0-323-02598-0 an arterial dye front-the angiographic feature with highest specificity]) is seen to travel very slowly to the peripheral retina along the branches of retinal arteries. Complete lack of filling of the retinal vessels is very rare. Delayed choroidal filling should point to an ophthalmic or carotid artery obstruction. Over time, the vessels re-open and flow reverts to normal, despite the persistence of retinal vessel narrowing. When retinal circulation re-establishes, the retinal fluorescein angiogram may be unremarkable, despite clinically pale retina, and cherry red spot, especially in cases where no emboli or boxcarring is clinically visible. Poor perfusion of the arterial tree can be demonstrated by the ability to induce retinal pulsations in the central retinal artery by digital pressure on the eyeball (ophthaldynomometry). [[File:CRAO FA 90s.jpg|thumb|Central retinal artery occlusion with delayed artery filling after 90s]] Electroretinography, ERG, shows a characteristic diminution of the b-wave. This is due to inner retinal ischemia. The ERG may be normal in some cases (despite poor visual acuity) if the blood flow renormalizes. == Laboratory test == An erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and complete blood count (CBC) with platelets should be obtained in patients over the age of 50 who have symptoms of giant cell arteritis (PPP Strong recommendation).<ref name=":0" /> Patients younger than 50 should have a hypercoagulable workup including antiphospholipid antibody syndrome, autoimmune conditions, inflammatory disorders, and other hypercoagulable states (PPP strong recommendation).<ref name=":0" /> In a young patient with multiple or recurrent BRAOs, Susac syndrome should be considered. In older individuals, atherosclerosis and emoboli are the most likely cause of the ischemia. Evaluation of the heart with echocardiography should be performed to determine cardiac function and abnormalities of the valves. Electrocardiograms and heart monitoring may reveal a rhythm defect. Cartotid artery stenosis should be evaluated with carotid ultrasound (PPP strong recommendation)<ref name=":0" /><br> == Differential diagnosis == Branch retinal artery occlusion: Sectoral whitening in the path of a branch retinal artery is pathognomic for a BRAO. Central retinal artery occlusion has retinal artery boxcarring and whitening in all four quandrants, with vision usually between 20/200 and hand motion Ophthalmic artery occlusion has both retinal artery findings as well as choroidal vascular nonperfusion. Vision is often no light perception. There is no cherry red spot as the choroidal perfusion is also occluded. Carbon monoxide poisoning may also present with a cherry red spot can also be caused by Ocular ischemic syndrome may present with transient symptoms of vision loss. There may be conjunctival injection and neovascularization of the anterior and posterior segment, with inflammation in the anterior chamber or vitritis. Optic nerve edema and retinal hemorrhages are often seen as well. Carotid disease is the most common cause. = Management = == General treatment == Acute symptomatic retinal artery occlusion should prompt immediate emergent referral to the nearast stroke center. However, the evidence is limited for asymptomatic BRAO. (PPP strong recommendation)<ref name=":0" /> == Medical therapy and follow up == Retinal artery occlusion is an eye emergency. Patients should be referred to the nearest stroke center for further immediate management. There are no evidence based therapies that have demonstrated efficacy in improving visual outcomes, and a meta-study has suggested that some therapies may be worse than the natural course.<ref name=":2" /> Some of these are described below. Clot busting tissue plasminogen activator (tPA) was evaluated in the [https://www.ncbi.nlm.nih.gov/pubmed/20609991 EAGLE study], which was a randomized controlled trial comparing intra-arterial fibrinolysis to placebo. The study did not recommend intra-arterial tPA for acute CRAO because of significant symptomatic intracranial hemorrhage without evidence of visual benefit.<ref>Schumacher, M. ''et al.'' Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial. ''Ophthalmology'' '''117,''' 1367–1375.e1 (2010).</ref> The trial was terminated early due to the adverse effects of tPA. A randomized controlled trial comparing intravenous tPA to placebo did not show improved short term visual benefit when given within 6 hours, but this was not sustained. <ref>Chen, C. S. ''et al.'' Efficacy of intravenous tissue-type plasminogen activator in central retinal artery occlusion: report from a randomized, controlled trial. ''Stroke J. Cereb. Circ.'' '''42,''' 2229–2234 (2011).</ref> There was no long term visual benefit and intracranial hemorrhage was an adverse reaction noted in this small study. Although recent meta-analysis of observation studies suggest that there may be mild benefit to intravenous tPA when given within 4.5 hours, they also reported several fatalities associated with tPA.<ref name=":2">Schrag, M., Youn, T., Schindler, J., Kirshner, H. & Greer, D. Intravenous Fibrinolytic Therapy in Central Retinal Artery Occlusion: A Patient-Level Meta-analysis. ''JAMA Neurol.'' '''72,''' 1148–1154 (2015).</ref> Their analysis also suggested that conservative treatments (ocular massage, paracentesis, hemodilution) led to worse outcomes.<ref name=":2" /> Ocular massage is a conservative therapy that may theoretically cause emboli to travel more distally to reduce the area of ischemia. A three-mirror contact lens is placed on the eye and pressure is applied for 10 s, to obtain retinal artery pulsation or flow cessation followed by a 5 s release.<ref>Cugati S, Varma DD, Chen CS, Lee AW. Treatment Options for Central Retinal Artery Occlusion. Curr Treat Options Neurol. 2013 Feb;15(1):63–77.</ref> Similar, anterior chamber paracentesis may be performed by removing 0.1-0.4 ml of aqueous fluid from the anterior chamber using a small gauge needle (27 or 30 gauge).<ref>Atebara NH, Brown GC, Cater J. Efficacy of anterior chamber paracentesis and Carbogen in treating nonarteritic central retinal arterial occlusion. Am J Ophthalmol 1995; 102:2029-2034.</ref> Theoretically, the paracentesis lowers the intraocular pressure and may allow the embolus (if any) to move further down the vessel and away from the central retina. In addition, the intraocular pressure may be decreased medically with eyedrops. If available, Increasing carbon dioxide concentration has also been proposed to induce vasodilation. The patient is instructed to breathe into a bag in order to increase carbon dioxide concentration.<ref>Frayser R, Hickham JB. Retinal vascular response to breathing increased carbon dioxide and oxygen concentrations. Invest Ophthalmol 1964;3:427-431.</ref> Alternatively, a patient may be given an oxygen mask to try to increase oxygen perfusion through the choroidal circulation. A mixture of 95 % oxygen and 5 % carbon dioxide has also been proposed to increase bloodflow. == Complications == Neovascularization of the iris, retina or angle are common complications after central retinal artery occlusion. This can cause further vision loss or pain in the affected eye. Findings of neovascularization may be delayed in patients treated with tPA or hyperbaric oxygen. This may be treated with anti-VEGF agents or may require surgery if it progresses to vitreous hemorrhage or uncontrolled glaucoma. Complications from invasive intervention with intravenous or intra-arterial tPA may include symptomatic intracranial hemorrhage, choroidal hemorrhage, or death.<ref name=":2" /> == Prognosis == Visual loss with CRAO is usually severe, and is strongly correlated with the amount of retinal edema.<ref name=":1" /> However, with CRAOs, in the presence of a cilioretinal artery, visual acuity usually recovers to 20/50 or better in over 80 % of eyes.<ref>Brown GC,and Shields JA. Cilioretinal arteries and retinal artery occlusion. Arch Ophthalmol 1979;97:84-92.</ref> Neovascularization may occur and patients should be followed closely.<ref>Duker JS, Brown GC. Neovascularization of the optic disc associated with obstruction of the central retinal artery. Ophthalmology 1989; 96:87-91.</ref><ref>Hayreh S and Podhajsky P. Ocular neovascularization with retinal vascular occlusion, II. Occurrence in central and branch retinal artery occlusion. Arch Ophthalmol 1982;100:1585-96.</ref> <ref>Rudkin AK, Lee AW, Chen CS. Ocular neovascularization following central retinal artery occlusion: prevalence and timing of onset. Eur J Ophthalmol 2010 May 28 Epub.</ref>Patients need to be examined for development of iris neovascularization, which has been reported to occur in 2.5 % to 31.6 % of patients. A recent study showed an prevalence of 18 % with a mean onset of 8.5 weeks post-occlusion. Visual field loss in BRAOs is usually permanent. Visual acuity may recover to 20/40 or better in 80 % of eyes. = Additional Resources = * See [[#References]] * Porter D, Vemulakonda GA. [https://www.aao.org/eye-health/diseases/stroke-affecting-eye Retinal Artery Occlusion]. American Academy of Ophthalmology. EyeSmart<sup>®</sup> Eye health. https://www.aao.org/eye-health/diseases/stroke-affecting-eye. Accessed March 25, 2019. = American Academy of Ophthalmology CME Resources = * [https://store.aao.org/focal-points-2010-module-retinal-arterial-occlusions.html AAO 2010 Focal Points: Retinal Artery Occlusions] * [https://www.aao.org/preferred-practice-pattern/retinal-ophthalmic-artery-occlusions-ppp-2016 AAO Retinal and Ophthalmic Artery Occlusions PPP - 2016] = References = <references /> Please note that all contributions to EyeWiki may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it. You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see EyeWiki:Copyrights for details). 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